Some major events in Alzheimer's are mediated by membrane proteins. The understanding of these events, it is vital for the development of highly effective therapeutic strategies. Our aim is to determine accurately and quantitatively the level of interaction of membrane proteins of interest. In the long term it is expected to have a detailed map of interactions that allow a rational design approach to gene therapy. These interactions will be measured with the help of spectrophotometric techniques and microscopy based on Forster Resonance Energy Transfer (FRET). These developments will be carried out both in model lipid bilayers and in living cells.