Detection of molecules is central to medical diagnostics. Ideally, they should develop miniaturized detection devices, highly biocompatible and freelancers. This requires work with platforms that provide real-time response to stimuli of relatively low magnitude. Additionally, to achieve miniaturization and implantation, it is essential that detection events occur on thin, flexible material. Graphene, meets the ideal characteristics for the manufacture of these devices: it has electrical properties that allow it to provide ultra-fast responses, its size and topology allow access to extremely small sizes and is made of carbon, a highly biocompatible material. Given the versatility of graphene, it is possible to use methods of transduction of various kinds including refractometric, colorimetric and fluorometric among many others.